TY - BOOK AU - Raman,Karthik AU - TI - An introduction to computational systems biology: systems-level modelling of cellular networks T2 - Chapman & Hall/CRC computational biology series SN - 9781138597327 U1 - 570.113 23 PY - 2021/// CY - Boca Raton, FL PB - CRC Press KW - Systems biology KW - Biological systems KW - Molecular biology KW - Computational biology KW - Computer simulation KW - Data processing N1 - Includes bibliographical references and index; Introduction to modelling; Introduction to graph theory; Structure of networks; Applications of network biology; Introduction to dynamic modelling; Parameter estimation; Discrete dynamic models: Boolean networks; Introduction to constraint-based modelling; Extending constraint-based approaches; Perturbations to metabolic networks; Modelling cellular interactions; Designing biological circuits; Robustness and evolvability of biological systems; Epilogue: The Road Ahead N2 - "This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks-a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. The book is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others"-- ER -